Nestor Cortes gave up three homers in the first inning while pitching for the Padres on Aug. 18, and ... that sounds familiar.

Flores went 1-for-3 with a two-run home run and a walk in Monday's 4-3 win over the Padres. Flores got the start at designated hitter, and he made an early impact by taking southpaw Nestor Cortes deep in the first inning.

The fiery right-hander tied a season-high with 10 strikeouts over six strong innings, Manny Machado ended a 14-game RBI drought and the Padres beat the Giants 5-1 in front of a sellout crowd of 40,624 to snap a four-game skid.

San Francisco Giants first baseman/designated hitter Wilmer Flores (hamstring) remains out of the lineup Saturday against the Washington Nationals. Rafael Devers will DH and bat second, while Dominic Smith will man first base and hit cleanup versus right-hander Brad Lord.

At PETCO Park on Wednesday, the San Francisco Giants face the San Diego Padres (four consecutive defeats) at 9:40 p.m. ET. The Padres are favored at home (-154) against the Giants (+130). The scheduled starters are JP Sears for the San Diego Padres, and Landen Roupp (7-6) for the San Francisco Giants.

The right-handed-hitting Flores will hit the bench for a fourth straight game, with the Giants having faced right-handed pitchers in each of those contests. He appears to have faded into the short side of platoon with the left-handed-hitting Dominic Smith,

DETROIT -- Wilmer Alejandro Flores, the 31-year-old infielder for the San Francisco Giants, took the traditional path to the big leagues for a youngster in Venezuela.

Heliot Ramos and Rafael Devers hit back-to-back then Wilmer Flores launches a two-run home run in the top of the 1st