In this review, we discuss evolving concepts in the diagnosis and prognosis of alcohol-associated hepatitis, the current trend to treat these patients in a holistic manner involving addiction ...

While heavy drinking is a well-established risk factor for liver cancer, the specific mechanisms by which alcohol contributes to A-HCC remain unclear. This insightful review, published in Hepatology, ...

A quantitative alcohol history should be recorded for all patients, because alcohol use contributes to many physical and mental disorders. A person-centered, nonjudgmental approach should be adopted.

Alcohol and its metabolites disrupt the gut barrier, leading to increased levels of pathogen-associated molecular patterns (PAMPs). These PAMPs trigger the recruitment and activation of immune cells, ...

In response to alcohol, various cellular and molecular changes occur in the liver, contributing to hepatic steatosis, inflammation and fibrosis. Hepatocytes exhibit increased production of reactive ...