Underscoring the entire schedule is that the 2025 campaign will be the last in their longtime home of Highmark Stadium, where they began playing in 1973. As their new stadium across the street is scheduled to be ready for the 2026 season, the Bills have one final chance to chase Super Bowl glory in their farewell season to their 53-year home.

The NFL officially released its full slate of games for the 2025 season on Wednesday. The schedule is full of intrigue as the Bills look to build toward their sixth-consecutive AFC East crown. However, Buffalo will face off against multiple teams that have ended their season in recent years.

ORCHARD PARK, NEW YORK - JANUARY 19: Lamar Jackson #8 of the Baltimore Ravens and Josh Allen #17 of the Buffalo Bills embrace after the AFC Divisional Playoff game at Highmark Stadium on January 19, 2025 in Orchard Park, New York. (Photo by Al Bello/Getty Images) Getty Images

Fresh off a heartbreaking loss to the Kansas City Chiefs in the AFC Championship Game last season, the Buffalo Bills are set to enter 2025 with Super Bowl aspirations.

In a surprise, one of the games the Buffalo Bills are playing in 2025 is amongst the most coveted contests across the entire NFL next season. The league released the entire schedule for the upcoming year this week, including the Bills' slate.

With the Texans' 2025 schedule out, The Houston Chronicle's Jonathan M. Alexander makes his week-by-week predictions for all 17 games.

The Ravens will play at least four prime-time games in 2025, including the season opener at Buffalo and a home game on Thanksgiving night.

NFL schedule is officially released and we have an exciting season coming up for the Buffalo Bills. The Bills are kicking off their season at home under the lights on Sunday Night Football against a team that they barely knocked out of the playoffs last season;