Relapsing after quitting cocaine is not simply a matter of willpower — it reflects physical changes in the brain, according to new research. Scientists have found that repeated cocaine use reshapes ...

A new study published in European Neuropsychopharmacology suggests that semaglutide, a drug already used to treat type 2 diabetes and obesity, may also help reduce cocaine use, drug-seeking behavior, ...

Scientists have found that the diabetes/weight loss drug Semaglutide, sold commercially under brand names like Ozempic and Wegovy, significantly reduces cocaine-seeking behaviour in rats. This work ...

Drug addiction carries an extremely high risk of relapse, as cravings can be reignited by minor stimuli even long after one has stopped using. Previously, this phenomenon was attributed to a decline ...

Cocaine, a drug of abuse, activates just a portion - 10 to 20 percent - of the neurons in the brain's nucleus accumbens, a critical region linked to motivation and addiction. Though small in numbers, ...

When considering the drugs most likely to cause former addicts to repeatedly relapse, opioids, cocaine, and methamphetamine ...

Serotonergic G-protein-coupled receptors (GPCRs), including the 5-HT2A receptor (5-HT2AR) and 5-HT2CR, are key regulators of cortical signaling pathways and promising targets for neurotherapeutic drug ...

A new study reveals how cocaine use alters brain circuits tied to memory and reward, leaving the brain more vulnerable to relapse.