DNA helicases are motor proteins that translocate along nucleic acids to separate complementary strands, a step essential for replication, repair and recombination. By unwinding duplex DNA and ...

Helicases are specialised enzymes that translocate along DNA to unwind duplex structures, a fundamental step in replication, recombination and repair. Members of the RecQ family, notably the BLM ...

RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors Drug works similarly to other DNA damage repair inhibitors, such as PARP inhibitors This class of ...