GDNF does not have a neuroprotective effect in this α-synuclein-induced toxicity model of PD In the paper by Decressac et al., 2 the authors questioned the relevance and predictability of toxin-based ...

Four different glial cell line-derived neurotrophic factor (GDNF)-family ligand (GFL)– receptor (GFRα) binding pairs exist, and they all signal through the transmembrane RET receptor tyrosine kinase.

New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems. In a new article ...

Protection Against High-Fat Diet-Induced Obesity – GDNF-tg mice exhibited significantly lower body weight and reduced fat deposition despite consuming a high-fat diet. Enhanced Fat Burning and Energy ...

Statistically Significant Reduction in Srebf1 (Fat Production) and Increased Pparα (Fat Metabolism) Position GDNF as Next-Generation Therapy for MAFLD and Obesity NEW YORK, April 13, 2026 /PRNewswire/ ...

The major goal of the research of Dr. Sidorova’s team in the Saarma lab is to develop neuroprotective and neuroregenerative drugs for disease-modifying treatment of nervous system disorders caused by ...

For the first time, researchers have witnessed dopaminergic neuron sprouting in a Parkinson disease (PD) patient treated with the neurotrophic factor GDNF. A postmortem examination of the brain of a ...

Pfizer has struck a deal with MedGenesis Therapeutix to license its glial cell line-derived neurotrophic factor (GDNF) protein and convection enhanced delivery (CED) technology to investigate ...

GDNF has been hailed as a potential breakthrough for Parkinson’s ever since it was discovered in 1993. In the lab, it was shown to bring dying brain cells back to life and it has proved to be ...

New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems. In an article ...