Previously shown to deliver morphine-comparable pain relief without opioid-related risks in a validated inflammatory pain model, supporting planned IND submission for inflammatory pain ...

Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression. Their illegal use contributes ...

An experimental drug developed at Duke University School of Medicine could offer powerful pain relief without the dangerous side effects of opioids. The drug, called SBI-810, is part of a new ...

Brixadi (buprenorphine) is a brand-name injection that’s prescribed for opioid use disorder. As with other drugs, Brixadi can cause side effects, such as injection site reactions and respiratory ...

Researchers have developed a compound that relieves pain in mice but doesn't affect the brain, thereby avoiding mind-altering side effects and abuse potential. The custom-designed molecule, derived ...

Kappa-opioid receptor (KOR) agonists represent a promising class of compounds that modulate pain, mood and various neurobehavioural processes. Unlike traditional opioids that primarily target the ...

The UK is in the grip of a massive opioid crisis and the government must get serious about tackling it. Opioids are ...

Naltrexone is a generic prescription drug used to treat certain substance use disorders. Naltrexone oral tablet does not come in any brand-name versions. This drug can cause mild to serious side ...

Researchers at USF Health have reported that they can guide opioid receptors to use a different internal signaling route, allowing pain relief while sharply reducing the risk of slowed breathing and ...