Video shows the mechanism of action of a polyketide synthase module reported by a University of Michigan research team. A new study solves long-standing mysteries about how bacterial ...
The alternative text for this image may have been generated using AI. Chemicals were purchased from Sigma-Aldrich and Roth. MALDI measurements were performed using an UltrafleXtreme MALDI TOF/TOF ...
Our society urgently requires a transition from fossil fuel dependence to a biosustainable economy. Engineering assembly-line or multi-domain megasynthases, such as type I polyketide synthases (PKSs), ...
A German-US coalition of researchers from Goethe University Frankfurt (Germany) and the University of Michigan (MI, USA) have added a new element to the production of an antibiotic, erythromycin, to ...
Polyketides are a large class of secondary metabolites that have become indispensible in the modern medicine. They are made by massive enzymes called polyketide synthases, which contain multiple ...
Tropane alkaloids, a broad class of natural products from plants, have been used as medicines for more than a century. Tropinone, the simplest tropane alkaloid, is a key intermediate in the synthesis ...
Tilting the scales at 4.7 megadaltons and reaching 1 micron in length, the newly discovered algal enzyme PKZILLA-1 is the largest protein ever identified in biology. Indeed, PKZILLA-1 is 25% larger ...
Polyketides produced by bacteria and fungi posess a very wide range of pharmaceutical properties, including antibiotic, antifungal, antitumor and antiparasitc activities. Extensive strain screening ...
Polyketides are a large class of secondary metabolites that have become indispensible in the modern medicine. They are made by massive enzymes called polyketide synthases, which contain multiple ...
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