AHA/ASA Journals

RND3 Enhances Cardiac Glucose Metabolism Through Inhibiting ACAT1-Dependent PDHA1 Acetylation and Protects Against Ischemia-Reperfusion Injury

BACKGROUND: Metabolic disturbances are key contributors to myocardial ischemia-reperfusion (I/R) injury, yet the underlying molecular mechanisms remain largely unclear. RND3, a cytosolic small GTPase ...
Nature

Pyruvate Carboxylase Function in Cancer Metabolism

Pyruvate carboxylase (PC) is a mitochondrial biotin-dependent enzyme that catalyses the ATP-dependent carboxylation of pyruvate to oxaloacetate, thereby replenishing tricarboxylic acid (TCA) cycle ...
Nature

Mitochondrial Pyruvate Transport and Metabolic Regulation

Pyruvate generated by glycolysis in the cytosol enters mitochondria via the mitochondrial pyruvate carrier (MPC) complex, a critical gateway linking cytosolic metabolism with the tricarboxylic acid ...
GEN

Structure of Mitochondrial Pyruvate Carrier Drug Target Bound to Inhibitors Revealed

Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...

Biohaven Reports First-in-Human Dosing of Oral PKM2 Modulator, BHV-8100, Targeting Metabolic Restoration and Immunomodulation

Biohaven Ltd. (NYSE: BHVN) ("Biohaven"), a global clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of life-changing therapies for rare and common ...