Discovering and bringing a new drug to market typically takes 14 years and costs approximately $ 2 billion USD. Today, the competitive landscape throughout the drug development process requires ...

While former tennis star Chris Evert has said that tennis player Maria Sharapova has no friends on the tennis tour, having "isolated herself," from other players, pharmacokinetics could end up being ...

A comprehensive overview of pharmacokinetics principles can be found in Chapter 5 of the widely used therapeutics textbook Pharmacotherapy: A Pathophysiologic Approach, 6th edition. [1] In addition, ...

Pharmacotherapy with the three Food and Drug Administration (FDA)-approved phosphodiesterase (PDE)5 inhibitors, sildenafil, vardenafil, and tadalafil, is currently the mainstay of treatment for ...

Irrespective of what therapeutic area or drug target a discovery program pursues, a common bottleneck that cannot be avoided is pharmacokinetics and safety. Thus, all drugs must enter the body, ...

In drug discovery trials, the potential for a molecule to do harm to an organism must be known accurately. Understanding how a substance under investigation behaves once in the body informs the design ...