Can VCU be one of the 2025 March Madness bracket busters beginning with No. 6 seed BYU on Thursday? Before making any 2025 NCAA Tournament predictions, see the 2025 March Madness bracket picks from the proven computer model at SportsLine.

In the first game No. 16 St. Francis (PA) will square off with No. 16 Alabama State, with a trip to Kentucky to take on the top overall seed Auburn on the line. In the second game, No. 11 North Carolina — a surprising inclusion in the tournament — takes on No.

Madness teams could pull off upsets in the first round? Here's eight bracket-buster predictions for Round of 64 NCAA Tournament bracket.