A mysterious and unpredictable group of side effects from modern medications called idiosyncratic drug reactions likely will persist as a major health care problem unless there is a dramatic increase ...

Drug-induced neutropenia and agranulocytosis represent serious adverse haematological conditions arising from the administration of a variety of therapeutic agents. These conditions involve a marked ...

The pathogenesis of idiosyncratic “hypersensitivity” reactions to the sulphonamides is thought to be mediated by reactive intermediates. We have previously demonstrated dose-related toxicity of ...

Phenotypes Acute hepatic necrosis, serum enzyme elevations, sinusoidal obstruction, acute fatty liver, nodular regeneration Acute hepatocellular hepatitis, mixed or cholestatic hepatitis, bland ...