New research indicates that drugs that target a cell growth pathway known as the JAK-STAT pathway are likely to be effective against certain chronic leukemias. Researchers recently discovered that a ...
Jonathan Silverberg, MD, PhD, MPH, associate professor of dermatology, director of clinical research and patch testing, George Washington University School of Medicine and Health Sciences, discusses ...
Mechanisms of acquired afatinib resistance in HER2-positive breast cancer cells. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I. This abstract does not include a full text ...
Asthma is a chronic respiratory condition marked by airway inflammation, narrowing, and episodes of wheezing, coughing, and shortness of breath. It affects millions of people worldwide and continues ...
Eosinophilic cellulitis (EC) is a type 2 inflammatory disease that activates the JAK1/JAK2-STAT5 pathways, an analysis of skin biopsy specimens suggests. To better understand the pathogenesis of EC, ...
The Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway was discovered 20 years ago as a mediator of cytokine signaling. Since this time, more than 2,500 articles have ...
Researchers have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues. Researchers at the Icahn School of Medicine ...
How the same enzyme helps protect brain cells from the destruction of Alzheimer's yet contributes to the blood vessel disease of diabetics is a puzzle Dr. Mario B. Marrero wants to solve. "I call JAK2 ...
Drug development based on Janus kinase (JAK) inhibitors hasn’t progressed as far as other biopharma specialties since the first such treatment won approval more than a decade ago. Ajax Therapeutics, a ...
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