NIK Signaling Functions Through Non-Canonical NF-κB Pathway and NF-κB-Independent Pathways (IMAGE)
NIK is the central regulator of the non-canonical NF-κB pathway, which is triggered by signaling from a subset of TNFR members. Upon receptor crosslinking by corresponding ligands, TRAFs and cIAP1/2 ...
New inhibitor of the noncanonical NF-κB pathway specifically binding to RelB shows antitumor effect
The transcription factor nuclear factor-κB (NF-κB) family has a central regulatory role in the expression of many genes related to immune responses, inflammation, cell survival and cancer. Previous ...
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