The Walt Disney Co. release is by far the biggest opener of 2025 and the company predicts it will hit $100 million domestically and $192.4 globally by the end of Monday's Presidents' Day holiday. It’s Marvel's first major release since “Deadpool & Wolverine” broke records last summer and re-energized a Marvel fanbase that some worried was weakening after the poor showing for “The Marvels.

Brave New World" opened to a mighty $100 million. But how will the superhero sequel hold in subsequent weeks at the box office?