Feb 3, 2025 · Under normal circumstances, menin is involved in blood development. It facilitates a complex of proteins involved in an epigenetic process that marks and unravels DNA to activate …

Menin, the protein product of the MEN1 gene, is essential for development and has been implicated in multiple different cancer types. These include leukemias and several different solid tumors, including …

Feb 6, 2025 · Here, we review the clinical value of menin inhibitors, highlighting their mechanism of action, efficacy, safety, and potential to transform AML treatment.

Sep 21, 2024 · Menin is increasingly recognized for its dual function as either a tumor suppressor or a tumor promoter in a highly tumor-dependent and context-specific manner.

Oct 29, 2025 · Revumenib, which was developed based on research conducted at Memorial Sloan Kettering Cancer Center (MSK), is the first drug in a new class of drugs called menin inhibitors to …

Germline mutations in the gene encoding menin cause the multiple endocrine neoplasia type 1 (MEN1) syndrome, a hereditary condition associated with tumors of the endocrine glands.

Jun 1, 2025 · Menin inhibitors are also being investigated in patients with newly diagnosed acute leukemia or as a maintenance therapy post allogeneic stem cell transplantation. This review provides …

Menin, the protein product of the MEN1 gene, is essential for development and has been implicated in multiple different cancer types. These include leukemias and several different solid tumors, including …

Dec 3, 2024 · How do menin inhibitors work? Menin inhibitors are medications used to treat patients one year and older, with relapsed or refractory acute leukemia, a type of blood cancer.

Menin is a protein involved in transcriptional regulation, impacting cell cycle control, apoptosis, and DNA damage repair. It plays a direct role in oncogenic signaling in multiple cancers.