Stage 4 prostate cancer means the cancer has spread to distant parts of the body, which is considered advanced. There is no ‘stage 5’ in the standard medical staging for prostate cancer.

Prostate cancer staging is based on how far the cancer has spread as well as the Gleason score and PSA levels. Learn more about prostate cancer stages here.

This stage of cancer is called locally advanced prostate cancer. It means the cancer has spread outside the prostate into local tissue, such as the seminal vesicles (the glands that make semen).

Jul 26, 2025 · A Gleason score of 9 or 10 indicates Grade Group 5, the most aggressive form of prostate cancer. In this group, cancer cells appear very abnormal, showing significant deviation from normal …

Aug 8, 2025 · Staging is a method cancer specialists use to indicate how advanced the cancer is — whether it's broken through the prostate's outer layer and spread to associated nearby organs, lymph …

Oct 31, 2025 · Prostate cancer can be classified into four stages, depending on how advanced it is. In stage 1, the tumor affects only your prostate and has not spread to other tissues. In stage 4, the...

Jun 23, 2022 · A combination of PSA levels, Gleason score, grade group and TNM staging determine prostate cancer stages 1-4. Learn about each stage and survival rate.

Knowing the stage of prostate cancer can help to determine how aggressively it needs to be treated and how likely it is to be removed by the available treatment options.

The stage of your cancer is part of what determines your Risk Group, which, in turn, informs your treatment options. It is considered in three levels: tumor in the pelvic area, spread to nearby lymph …

May 15, 2025 · Doctors now use your Grade group or Gleason score to divide prostate cancer into 5 groups. This is called the Cambridge Prognostic Group (CPG).