When I diagnose Mast Cell Activation Syndrome (MCAS), I use the Consensus 2 criteria. This method moves beyond the traditional tryptase-level criteria of Consensus 1, and focuses instead on symptom charts, response to treatment and specific lab tests. I’ve found this method to work impeccably. Many practitioners are not aware of mast cell activation syndrome and the complexity of how it can present, or either continue to use the outdated Consensus 1 approach or, worse, revert to an understanding

Mast Cell Activation Syndrome (MCAS) often flares when oxidative stress is high, pushing mast cells to release histamine and inflammatory cytokines. Superoxide Dismutase (SOD) is your body’s first defense against that stress—neutralizing superoxide radicals before they can trigger mast cell overactivity. By supplementing with a validated form like VARS SOD, you can calm inflammation at the root, reduce histamine-driven symptoms, and support better stability for those living with MCAS. Find VARS